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Posts : 77 Join date : 2010-04-06
| Subject: know sth about D-tert-Leucine Tue Apr 20, 2010 3:25 am | |
| Leucine (abbreviated as Leu or L) is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH(CH3)2. It is an essential amino acid, which means that humans cannot synthesise it. With a hydrocarbon side chain, leucine is classified as a hydrophobic amino acid. It has an isobutyl R group. Leucine is a major component of the sub units in ferritin, astacin and other 'buffer' proteins. Leucine and isoleucine belong to the proteinogenic amino acids; the others are non-natural. Including the stereoisomers, six further isomers could be added: D-leucine, D-isoleucine, L-allo-isoleucine, D-allo-isoleucine, D-tert-Leucineand D-norleucine. As an essential amino acid, leucine is not synthesized in animals, hence it must be ingested, usually as a component of proteins. It is synthesized in plants and microorganisms via several steps starting from pyruvic acid. The initial part of the pathway also leads to valine. The intermediate α-ketovalerate is converted to α-isopropylmalate and then β-isopropylmalate, which is dehydrogenated to α-ketoisocaproate, which in the final step undergoes reductive amination. | |
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