The pharmacological effects of Imatinib mesylate

Imatinib mesylate, the chemical name 4 - (4 - methyl -1-- yl) methyl-N-4-methyl--3-4-- (3 - pyridyl) -2-- pyrimidine aminophenyl - aniline sulfonate, molecular formula C29H31N7O • CH4SO3, molecular weight is 589.7.
Imatinib mesylate in vivo at the cellular level can be inhibited Bcr-Abl tyrosine kinase, can selectively inhibit Bcr-Abl-positive cell lines, Ph chromosome positive chronic myeloid leukemia and acute lymphoblastic leukemia The patient's fresh cell proliferation and induced apoptosis. In addition, imatinib mesylate also inhibits platelet derived growth factor (PDGF) receptor, stem cell factor (SCF), c-Kit receptor tyrosine kinase, thereby inhibiting the PDGF and stem cell factor-mediated Behavior.